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Lp-PLA₂: an emerging biomarker of coronary heart disease

- Intravascular highly specific inflammatory factors

- Independent risk predictors of cardiovascular and cerebrovascular diseases

Lp-PLA₂ induces an increase in plaque instability, making the plaque fragile and ruptured, leading to thrombosis and ischemic stroke. In addition, high levels of Lp-PLA₂ predict increased instability of atherosclerotic plaques, more prone to rupture, and increased risk of cardiovascular and cerebrovascular malignant events.Schematic diagram of Lp-PLA₂ is shown in Figure 1.

Figure 1

Schematic diagram of Lp-PLA₂ and plaque stability

References:

The international recognition and importance of Lp-PLA₂ is gradually increasing, and it is recommended that Lp-PLA₂ be used in various aspects of cardiovascular and cerebrovascular diseases such as screening, differential diagnosis, risk assessment, treatment and prognosis.Guideline Recommendation Table is shown in Figure 2.

Figure 2

Lp-PLA₂ Guideline Recommendation Table

Clinical significance: 

-Dynamic monitor of the degree of inflammation in the vascular endothelium and atherosclerotic plaques

-Risk estimation for coronary heart disease and stroke

-Estimated risk of recurrence for various cardiovascular embolisms (stroke)

-Efficacy assessment , the decreased level of Lp-PLA₂ is positively correlated with the lipid-lowering effect of statins

Applicable departments: 

Cardiology, cardiac surgery, neurology, veteran department, endocrinology, laboratory department, physical examination center