The reagent is used to quantitatively detect the content of β2-microglobulin (β2-MG) in human urine, serum, plasma or whole blood in vitro. It is mainly used to monitor the function of proximal renal tubules clinically.
Applicable to various sample types of serum, plasma, whole blood and urine
Rapid detection of single reagent (10 minutes)
Convenient storage and transportation at room temperature
Acute kidney injury (AKI) refers to the abnormality of kidney structure and function (including abnormal blood, urine, histology and imaging examination) within 3 months of disease course. resulting in clinical syndromes with different clinical manifestations.
In recent years, some new and more sensitive biomarkers of AKI have been discovered in clinical and laboratory studies, which can not only diagnose AKI before serum creatinine rises, but also provide help for the etiological diagnosis of AKI.
NGAL The best index for early diagnosis of acute kidney injury
CYS-C The best endogenous index of glomerular filtration rate
β2-MG Monitoring indicators of proximal tubule function
MAU Sensitive indicator of early or mild kidney injury
β2 Microglobulin (β2-MG)
The synthesis rate of β2-MG in healthy people is very stable, and it is only decomposed and excreted by the kidneys, and is not affected by factors such as age, gender, and muscle. The increase of β2-MG in plasma reflects the impairment of glomerular filtration function or the increase of filtration load; the increase of β2-MG in urine indicates the increase of renal tubular damage or load.
Clinical application of blood β2-MG：
- For estimation of renal function disorders
a. Assessment of renal impairment in hypertension and diabetes
b. Dynamic observation and diagnosis of renal transplant rejection
- Prognosis and therapeutic effect evaluation of malignant tumor diseases
- Autoimmune disease assessment and efficacy monitoring
Clinical application value of urinary β2-MG
- Sensitive and specific method for the diagnosis of proximal convoluted tubule damage
- For the identification of upper and lower urinary tract infections
- Used to determine rejection of kidney transplantation, and a marked increase is seen several days before rejection
Nephrology, emergency, interventional, ICU, cardiology, surgery
|Sample type||serum, plasma, whole blood,urine|
|Storage||4-30℃, sealed and kept away from light and dry|
|Validity period||18 months|
|Specifications||25 tests/box, 50 tests/box|